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A two-week gap separated every two courses, during which tamoxifen citrate (40 mg per day) and clomiphene citrate (10 mg per day) were taken to control serum testosterone levelsand the hormonal profile. Both tamoxifen citrate (40 mg per day) and clomiphene citrate (10 mg per day) are known to increase serum testosterone levels by an average of 5 to 10% (24) and 3 to 4%, respectively. We also used a combination of oral testosterone enanthate (5 mg per day) and clomiphene citrate (15 mg per day) to control the testosterone levels and the hormonal profile in the postmenopausal women. However, since a greater absolute testosterone increase occurs with testosterone supplementation than the reduction in sex hormone levels, we did not select the combination of testosterone preparations for the preclinical model. Both oral testosterone enanthate and clomiphene citrate increase the blood testosterone in postmenopausal women by about 9% and 11%, respectively, with both preparations increasing testosterone levels of about 9% and 13%, respectively, even in a 3-week treatment period (24). We studied the effects of the combination of oral testosterone enanthate and clomiphene citrate (15 mg per day) and testosterone enanthate plus cyproterone acetate (20 mg per day) on serum total testosterone, free testosterone, and nonassociative sex hormone binding globulin (SHBG) and SHBG and testosterone levels in women with moderate-to-severe PCOS with high or low testosterone levels (25). The combination of testosterone enanthate (40 mg per day) and clomiphene citrate (10 mg per day) resulted in a significant increase in testosterone (P = 0.008), and the serum testosterone level was unchanged with both preparations; this increased total testosterone by 19% in PCOS women with serum testosterone levels between 40 nM and 60 nM. The combination of oral testosterone enanthate and clomiphene citrate (15 mg per day) increased SHBG levels by 11% with both preparations; these increased SHBG levels by 24.5 ± 7% and 17% in PCOS women with serum SHBG levels between 40 nM and 60 nM, respectively. We observed significant correlations between total testosterone, SHBG, and SHBG and SHBG levels between 50% and 80% (Fig. 2B) and between testosterone and SHBG levels (Fig. 2C) and between testosterone and SHBG levels (Fig. 2D) and between total and SHBG levels (Fig. 2E). The higher total or SHBG values in the premenopausal women with Related Article: